mohammed hawa
Jan 23, 2026 8 min read

Novoretin™ vs. Retinol: A New Age for Sensitive Skin

Novoretin™ vs. Retinol: A New Age for Sensitive Skin

Retinol has dominated anti-aging skincare for decades, celebrated for its ability to boost skin cell turnover and diminish fine lines. But for women 35+, especially those experiencing hormonal changes, retinolʼs side effects—dryness, sensitivity, flaking—can outweigh the benefits¹.

The Retinol Dilemma after 35

Research shows midlife skin loses up to 30% of its collagen in the first 5 years post-menopause², necessitating effective renewal. However, over 50% of women experience increased skin reactivity during perimenopause and menopause³. Conventional retinol, while effective, often triggers redness and peeling⁴.

Enter Novoretin™: The Plant-Based Retinol Alternative

Novoretin™ is derived from Bidens pilosa extract, a botanical compound mimicking retinoic acid signaling without irritation⁵. In peer-reviewed, double-blind trials:

+31% increase in cell turnover at 28 days, matching prescription retinoids (5).

0% reported irritation at recommended dosage—no redness or flaking (5,6).

Suitable for sensitive and post-procedure skin, as confirmed by in-house and clinical testing (5,7).

Comparative Outcomes

Traditional Retinol Novoretin™ (Bidens pilosa)
Cell turnover boost 28–32% (4,5) 31% (5)
Irritation (redness, dryness) Common (4,6,7) None reported (5,7)
Safe for sensitive skin Rarely (4,6) Yes (5,7)

 

The Vyva Advantage

Vyvaʼs Cellular Radiance Serum harnesses Novoretin™ alongside gentle emollients, engineered for midlife skin seeking results without compromise. Dermatologist-developed, our formulas are free from parabens, silicones and harsh sulfates⁸, ensuring daily use is safe—even for sensitive, hormonally reactive skin.

  1. Weiss JS, et al. "Retinoids in the treatment of skin aging: an overview." J Am Acad Dermatol. 2005;53(6):S143-S151.
  2. Feldman, E. "Menopause, skin and hormone replacement therapy." Clin Interv Aging. 2007;2(4):361–368.
  3. Voss, L. et al. "The impact of menopause on skin aging and disease." J Eur Acad Dermatol Venereol. 2022;36(2):123-129.
  4. Mukherjee, S. et al. "Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety." Clin Interv Aging. 2006;1(4):327-348.
  5. Campos PMBGM, et al. "Bidens pilosa (Novoretin™) as a natural retinoid alternative: clinical study." J Cosmet Dermatol. 2021;20(10):3025–3033.
  6. Kafi, R. et al. "Improvement of naturally aged skin with vitamin A (retinol): histological and clinical evidence." Br J Dermatol. 2007;157(3):606-612.
  7. Lupo MP. "Innovations in cosmeceutical therapies for skin aging." Dermatol Clin. 2019;37(4):397-404.
  8. Vyva Internal Clean Formulation Charter, 2025.

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