Q-Actin® — Cucumis sativus Extract (idoBR1)

What it does: Plant-derived iminosugar (idoBR1) studied for its role in inflammatory pathway research. Supports joint comfort and mobility.

• In a 180-day randomized double-blind trial, 20 mg Q-Actin® daily reduced WOMAC joint scores by 70.3% — vs 33.7% for 2,700 mg glucosamine-chondroitin (Nash et al., 2018, PMC6207263). Individual results may vary.
• In a separate 60-day randomized placebo-controlled trial, 20 mg/day Q-Actin® improved WOMAC by 31.79% from baseline at Day 60 (Hausenblas et al., 2025, Cureus 17(9):e93507, NCT06246383)
• Standardized to >1% idoBR1 — the active iminosugar amino acid
• Cucumber-derived (not shellfish-derived like glucosamine — safe for shellfish allergies)
• Safety: NOAEL ≥1,000 mg/kg/day over 90 days, no genotoxicity (Kothari et al., 2018, Toxicology Reports, PMC6224328)

In Vflex: 20 mg per gummy (verified by FARE Labs at 22.4 mg measured). One gummy daily.

Ioniplex® — Patented Fulvic Ionic Mineral Complex

What it does: Delivers 65+ trace minerals in ionic fulvic form. Designed to support cellular mineral nutrition — the foundation for skin, hair, nail, and connective tissue maintenance.

• Manufacturer laboratory data on file describes activity on cellular collagen pathways and mitochondrial-pathway metabolism in vitro (Sunny Biodiscovery Reports 697-BIOAV, 400COL, 466A)
• Six-week clinical evaluation on oral Ioniplex on nail condition: randomized, double-blind, placebo-controlled (Boisits 2009, Study No. 3411BK0609)
• Two issued US patents (Mineral, Cosmetic, Pharmaceutical, and Agriculture Compositions + Anti-Glycation Methods and Compositions) plus one pending
• Manufacturer Ioniplex® White Paper (Mineral BioSciences, October 2021)

In Vioni+: 208.14 mg per gummy (verified by FARE Labs). One gummy daily.

MitoPrime® — 98%+ Pure L-Ergothioneine

What it does: L-ergothioneine is an amino acid your body actively conserves through a dedicated transporter (OCTN1). Proposed as a putative longevity vitamin candidate by Bruce Ames (PNAS, 2018) — a hypothesis paper, not an established conclusion. We always include the "putative" qualifier.

• Ames B.N. (2018) — "Putative longevity vitamins" hypothesis in Proceedings of the National Academy of Sciences
• NNB-001 Lifespan Study (2021) — InVivo Biosystems C. elegans evaluation
• Distribution and accumulation in mouse tissues (2017) — pharmacokinetic research
• NNB safety evaluation supporting dietary supplement use
• Studied in healthy adults aged 50–78 over 12 weeks (Lloyd et al., 2025, Frontiers in Nutrition 12:1563999, NCT05878847). Findings included signals on sleep quality and finger dexterity. Individual results may vary.

In MitoV+: 5 mg L-ergothioneine per gummy as MitoPrime® (verified by FARE Labs at 4.78 mg measured, meets NLT 90% spec).

PhytoCellTec™ Malus Domestica

What it is: Plant cell culture extract from the Uttwiler Spätlauber Swiss apple variety. Mibelle Biochemistry's cosmetic ingredient research describes appearance benefits in firmness and dermal density at the studied active concentration (Schmid & Zülli, SPC Magazine 02/2010; SöFW Journal May 2008).

In Cellular Renewal Serum: 0.10% finished-product concentration.

MossCellTec™ N°1

What it is: Cosmetic active derived from Physcomitrella patens callus extract. Mibelle's cosmetic ingredient research positions it for appearance benefits related to skin resilience. Anchors both our Cellular Renewal Serum and our Cellular Clarity Serum — connecting the resilience and tone narratives.

In Renewal & Clarity: 2.00% raw concentration in both serums.

Salmon-Derived DNA Polynucleotide Complex (Sederma DNA Gel™ PH)

What it is: A cosmetic ingredient delivering DNA polynucleotide chains in a hyaluronic-acid gel base. Salmon soft-roe origin. EU INCI on the label: "DNA" (CAS 9007-49-2). Supports the appearance of firmer, more resilient-looking skin.

In Cellular Renewal Serum: 0.15% DNA in the finished serum (from 5% Sederma DNA Gel™ PH raw).

Hyaluronic Acid Systems — Hybloom™ HA-TP + Hymagic™ 4D

Hybloom™ HA-TP — multi-molecular-weight cosmetic sodium hyaluronate, used in Cellular Renewal Serum and Cellular Clarity Serum for cosmetic surface hydration.

Hymagic™ 4D — four-form HA system in Cellular Radiance Night Serum:

1. Sodium hyaluronate crosspolymer — long-lasting surface hydration film
2. Sodium hyaluronate — mid-MW dermal plumping (the workhorse)
3. Sodium acetylated hyaluronate — enhanced affinity, longer-staying
4. Hydrolyzed sodium hyaluronate — small-MW deeper-reaching cosmetic hydration

Delentigo™ — Targeted Tone-Evening Active

What it is: A Mibelle cosmetic active combining Swiss garden cress (Lepidium sativum) sprout extract with soy isoflavones (genistein) and lecithin. Designed to support the appearance of fading age spots while leaving surrounding skin tone unchanged.

In Mibelle's 8-week cosmetic study at 4% Delentigo® concentration, the difference in melanin index between the appearance of age spots and surrounding skin decreased by approximately 50%, while surrounding skin tone was unchanged (SöFW Journal May 2009; CosmeticsDesign 2010; HPC Today April 2010; Pure Health Autumn 2010). Individual results in finished VyVa Cellular Clarity Serum may vary.

In Cellular Clarity Serum: 4% raw — same concentration Mibelle's clinical research studied.

NovoRetin™ — Plant-Derived Retinol Alternative

What it is: A cosmetic active derived from Pistacia lentiscus (mastic) gum, delivered in a caprylic/capric triglyceride matrix. Mibelle's cosmetic ingredient research documents NovoRetin™ as supporting the skin's own retinoid signaling — without introducing exogenous retinoic acid. 28-day cosmetic studies at the studied active concentration describe appearance improvements in firmness and density (Personal Care Magazine July 2022; HAPPI Magazine June 2024).

In Cellular Radiance Night Serum: 3% raw. Vegan. Night-only use. Broad-spectrum SPF essential next morning.

Azeloglycine (Potassium Azeloyl Diglycinate)

What it is: A derivative of azelaic acid, widely used in cosmetic formulations for soothing properties and cosmetic tone-evening appearance benefits.

In Cellular Clarity Serum: 0.60% (meaningful concentration — a supporting hero active in the formula).

Sodium Ascorbyl Phosphate (Stabilized Vitamin C)

What it is: The stabilized, pH-neutral, non-acidic form of Vitamin C. Designed for cosmetic appearance benefits relating to brightness and antioxidant support, without the irritation associated with L-ascorbic acid.

In Cellular Clarity Serum: 0.10%.

Vitamin Tree (Hippophae rhamnoides / Sea Buckthorn)

What it is: Sea buckthorn berry extract with a history in skin care for its carotenoid and omega-7 content. Cosmetic ingredient research describes appearance benefits relating to skin radiance and barrier comfort.

In Cellular Radiance Night Serum: 2% raw → 0.006% Hippophae rhamnoides fruit extract in finished serum.

Lipomoist™ 2013

What it is: A peptide-mimetic hydration complex used in cosmetic formulations to support sustained cosmetic hydration.

In Cellular Radiance Night Serum: 0.10% raw.

Viapure™ Licorice White (Glycyrrhiza glabra Root Extract)

What it is: Traditional botanical with cosmetic ingredient research supporting its use for soothing and tone-evening appearance benefits.

In Cellular Radiance Night Serum: 0.001% finished concentration.