Surface renewal without retinol.
NovoRetin™ is not retinol and not a retinoid — it works with the retinoic acid your skin already makes. In its maker’s split-face study, 3D scanning thirty minutes after a single application recorded the appearance of wrinkle depth down 14.0% against placebo. Over 28 days at 2%, skin density improved 13.8% against placebo. Ours is 3%.
60-day refund — opened or not, nothing to send back · Free US shipping · Full INCI published
- Not retinol. Its own ingredient — NovoRetin™ at 3%
- Top of its 2–3% range — 1.5× the level its maker studied
- Mastic gum is a documented contact allergen — patch test 48 hours first
- Night use only · vegan · made in France

Thirty minutes. Then look again.
Most night serums ask for six weeks of faith. In its maker’s split-face study on 22 women aged 42 to 65, a single application of NovoRetin™ was measured by PRIMOS 3D structured-light scanning exactly thirty minutes later: against placebo, the appearance of wrinkle depth was down 14.0%, wrinkle length down 13.7% and roughness down 6.4%. 82% of the volunteers said the eye contour looked immediately smoothed and lifted.
Not a blur and not a filler — the geometry was scanned. It isn’t retinol either: instead of adding a retinoid, it works with the retinoic acid your skin already makes, and in its studies hydration went up rather than down.
Over 28 days at 2%, skin density improved 13.8% against placebo (Dermalab® ultrasound, n=18 women aged 42 to 70), while skin elasticity improved 20.4% against their own starting condition (Cutometer) — we publish which comparison each number came from, because they are not the same claim. Pore count fell 30.3% inside two weeks.
Ours is 3%, half again above the studied level. Made in Carros, France. Results refer to the appearance of skin.
Radiance and evenness of tone, measured on seventy-two women.
Plenty of “natural retinol alternatives” are studied on one narrow group and then sold to everyone. NovoRetin™ went through a separate 28-day split-face study against placebo on 72 women with Fitzpatrick IV–V skin, measuring brightness and evenness of tone.
88% showed improved brightness, against 33% on placebo.
Glow and evenness, measured on skin that most ingredient files never include. Results refer to the appearance of skin.
The maker’s numbers, and the allergen, both on the front.
Where a number is measured against placebo we say so, and where it is measured against the volunteer’s own starting condition we say that instead. They are not the same claim. Skin is individual — we will not print a date for your face.
- Evidence tier
- Supplier research — Mibelle Biochemistry’s ingredient studies, not independent studies of this finished serum.
- The key numbers
- At 30 minutes after one application, against placebo: appearance of wrinkle depth −14.0%, length −13.7%, roughness −6.4% (PRIMOS 3D scanning, n=22). At 28 days at 2%: skin density +13.8% against placebo; skin elasticity +20.4% against baseline. Ours is 3% — above, and printed.
- What we claim
- Appearance of smoothness and surface renewal.
- Published with your order
- Full INCI, allergens first: mastic gum — patch test 48 hours.
Night. Build up if you’re new to actives.
Clean, dry skin.
A few drops before moisturiser. New to evening actives? Start every other night.
Sunscreen in the morning, always — standard practice with any renewal active.

A different route to surface renewal.
Retinol asks for an adjustment period and careful layering. NovoRetin™ takes a different route — raising the retinoic acid your skin already produces — with the allergen it carries named on the front.
- NovoRetin™ — 3% — mastic-tree derived; half again above the studied 2% level
- The allergen, named — mastic gum is a documented contact allergen — patch test first
- Everything else — sea buckthorn, licorice root, hyaluronic acid — base conditioners at trace levels. Named on the label, claimed nowhere.
Every active, and how much of it is in the bottle.
Ingredient lists use INCI names, which is why a hero active can hide inside words like “pistacia lentiscus (mastic) gum” or “hippophae rhamnoides fruit extract”. So here is the plain version: what we call each active, and how much of it is in the finished serum.
Source: the INCI declaration printed on the carton.
- NovoRetin™ · 3.000%
- Vitamin tree (sea buckthorn) · 2.000% — a botanical, not a dosed active
- Licorice root — glycyrrhiza glabra root extract
- Hyaluronic complex — four hyaluronate weights, blended
- Lipomoist — carrageenan-based conditioning blend
The complete INCI list, exactly as it appears on the carton aqua (water), glycerin, polysorbate 20, pistacia lentiscus (mastic) gum, hippophae rhamnoides fruit extract, glycyrrhiza glabra (licorice) root extract, sodium acetylated hyaluronate, sodium hyaluronate, sodium hyaluronate crosspolymer, hydrolyzed sodium hyaluronate, glucose, chondrus crispus (carrageenan) extract, 1,2-hexanediol, hydroxyethylcellulose, propanediol, hydroxyacetophenone, caprylic/capric triglyceride, butylene glycol, lecithin, caprylhydroxamic acid, hexanediol, sodium nitrate, glyceryl caprylate/caprate, disodium phosphate, sodium phosphate, ethylhexylglycerin, polysorbate 60, xanthan gum, caprylyl glycol, phenoxyethanol, pentylene glycol
The full label — Supplement Facts
Thirty minutes. Then look again.
Most night serums ask for six weeks of faith. In its maker's split-face study on 22 women aged 42 to 65, a single application of NovoRetin™ was measured by PRIMOS 3D structured-light scanning exactly thirty minutes later: against placebo, the appearance of wrinkle depth was down 14.0%, wrinkle length down 13.7% and roughness down 6.4%. 82% of the volunteers said the eye contour looked immediately smoothed and lifted. Not a blur and not a filler — the geometry was scanned.
It is not retinol, and that is the point rather than the apology. Retinol adds a retinoid to your skin, with the dryness that comes with it. NovoRetin™, derived from mastic gum, takes a different route to smoother-looking skin, without the retinoid adjustment period — and in its maker's studies it increased hydration instead of causing dryness.
Over 28 days at 2%, skin density improved 13.8% against placebo (Dermalab® ultrasound, n=18 women aged 42 to 70), while skin elasticity improved 20.4% against their own starting condition (Cutometer). We publish which comparison each number came from, because they are not the same claim. Pore count fell 30.3% and pore volume 41.7% within two weeks.
A separate 28-day split-face study against placebo ran on 72 women with Fitzpatrick IV–V skin, measuring brightness and evenness of tone: 88% showed improved brightness against 33% on placebo.
We use it at 3% — 1.5× the studied concentration. Everything else in the bottle is base: sea buckthorn, licorice and hyaluronic acid sit at trace levels, and we claim nothing for them. Applied in the evening. Made in Carros, France.
The research is Mibelle Biochemistry's own, into the ingredient rather than into this finished serum.
Contains mastic gum, a documented contact allergen. Patch test on the inner arm and wait 48 hours before first use; stop if you react. For external use only. Avoid the eye area. Use broad-spectrum SPF 30+ each morning. Results refer to the appearance of skin and vary between individuals.
The VyVa Standard
Every active we use is named, and its amount is printed: milligrams on our supplements, percentages on our serums. There are no proprietary blends, and each product's full formula, its Supplement Facts or its full INCI, is published on its page before you buy.
Everything on this page can be checked. That's the entire pitch.
- 30 ml — roughly two months
- Vegan · contains mastic gum
- Formulated in France
- Full INCI published
Safety Contains mastic gum. Patch test 48 hours before first use.
Safety For external use only. Avoid the eye area. Patch test 48 hours before first use. Discontinue use if irritation occurs. Use sunscreen when exposed to sunlight. Keep out of reach of children.
Safety Discontinue use and consult a physician if irritation or unexpected reaction occurs. Not recommended for individuals sensitive to any ingredient in this product.
FAQ
Is it a retinoid?
Can I use it with acids?
Is it vegan?
When will I see something?

Sixty days. Then decide.
If it isn’t for you, tell us and we’ll refund it — opened or not. Keep the bottle; there’s nothing to send back. Sixty days is a refund window, not a results window.
For external use only. Avoid the eye area. Patch test 48 hours before first use. Discontinue use if irritation occurs. Use sunscreen when exposed to sunlight. Keep out of reach of children. Results refer to the appearance of skin. Individual results may vary. NovoRetin is a registered trademark of Mibelle AG.
