mohammed hawa
Jan 23, 2026 4 min read

Targeting Hyperpigmentation After 35: The Delentigo™ Difference

Targeting Hyperpigmentation After 35: The Delentigo™ Difference

Vyva™ Cellular Clarity Serum features Delentigo™, a patented dual-pigment technology for brighter, even skin tone—backed by clinical studies for women dealing with hormonal pigmentation changes.

The Pigmentation Problem

As estrogen levels drop, melanin production can become uneven. Age spots, dark patches, and dullness increase after sun, hormones, and stress all accelerate these changes.

Delentigo™: Dual-Target Technology

Delentigo™ is clinically shown to:

Reduce melanin clusters by 42% in 8 weeks.

Fade both melanin and lipofuscin (age pigments) simultaneously.

Deliver significant tone and clarity improvement for hormonal/age-related pigmentation.

Vyva's Multi-Tasking Formula

Vyva blends Delentigo™ with stabilized Vitamin C, kojic acid, and soothing

botanicals for gentle, daily clarity—no harsh bleaching, no post-inflammatory darkening.

Clinical Benefits

Brightness and uniformity improved in sensitive skin types safe for midlife, post-procedure, and reactive skin.

  1. Passegué E, Mostoslavsky R. Melanin, Hormones, and Photoaging: Biology of Pigmentation. J Invest Dermatol. 2022;142(5):1398-1402.
  2. Würz T, et al. Delentigo™: clinical efficacy in age spot fading. Int J Cosmet Sci. 2019;41(2):180-189.
  3. Tsukahara K, et al. Lipofuscin and pigment changes with age and hormonal fluctuation. Exp Dermatol. 2018;27(7):802-807.

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