The cosmetic research behind our four-active French serum

Schmid & Zülli (2010) — An Apple a Day: Plant Stem Cells for Skin

SPC Magazine, 02/2010. Mibelle Biochemistry technical publication.

Cosmetic ingredient study of PhytoCellTec™ Malus Domestica — plant cell culture extract from the Uttwiler Spätlauber, a rare Swiss apple variety known for its post-harvest resilience. 28-day cosmetic clinical evaluation at the studied active concentration.

Important context. Mibelle's research was conducted at the supplier's studied concentration. In Cellular Renewal Serum, PhytoCellTec is present at 0.10% — lower than Mibelle's research range. We frame appearance benefits in cosmetic-appearance language only, never as drug-tier structural changes.

Plant Stem Cell Extract for Longevity of Skin and Hair

SöFW Journal, May 2008. Mibelle Biochemistry.

Foundational publication establishing the plant stem cell extract category in cosmetic ingredient science. Reviews the biology, sourcing, and cosmetic application of plant cell culture extracts.

Stimuli for Skin Stem Cells (April 2009) + Stimulating Epidermal Regeneration with Plant-Derived Stem Cells (May 2010)

HPC Anti-Aging Beauty Inside, April 2009 + C&T Magazine, May 2010.

Category-level cosmetic science reviews on plant-derived cell culture extracts and their appearance benefits.

MossCellTec™ N°1 — Physcomitrella patens callus extract

Mibelle Biochemistry's moss-cell biotech ingredient, positioned for cosmetic appearance benefits relating to skin resilience. Cosmetic ingredient research supports the supplier's positioning for the studied active.

Cross-product story. MossCellTec™ N°1 is the same active at the heart of our Cellular Clarity Serum. Two formulations share the active — because resilient-looking skin and even-looking tone are connected concerns in cosmetic ingredient science.

Sederma DNA Gel™ PH — Salmon Soft-Roe Origin DNA Polynucleotide Complex

EU INCI: DNA (CAS 9007-49-2). Source: Salmon (Oncorhynchus spp.) soft roe. Delivered in a hyaluronic-acid gel base.

The salmon source is used because its DNA has structural similarity to human DNA, and the purification process removes proteins and lipids, leaving polynucleotide chains.

What we don't claim. The published research on polynucleotides primarily concerns injectable medical applications in markets outside the US (Rejuran, Placentex). Those applications are not legally available as drugs in the US without an FDA-cleared IND. Our serum is a topical cosmetic. We do not claim DNA repair, regeneration, fibroblast stimulation, or any pharmaceutical-tier benefit. The 0.15% DNA concentration in our finished serum is far lower than what injectable research studies use — supplier research at injectable concentrations does not transfer to topical-cosmetic claims.

Hybloom™ HA-TP — Multi-molecular-weight cosmetic hyaluronic acid

Bloomage Biotech is the world's largest cosmetic-grade hyaluronic acid producer. Hybloom™ HA-TP is their multi-MW cosmetic line, delivering hyaluronic acid in varied molecular weights designed for cosmetic surface hydration and the appearance of plumper-looking skin.

Hyaluronic acid is one of the most studied cosmetic ingredients globally — established for the look of skin hydration and surface smoothness.

Manufactured in France by EC&P (Europe Cosmétiques et Parfums)

Locked formula FOR.25.186.01, version 01, dated 08 August 2025. Manufactured under EU Cosmetics Regulation 1223/2009 — the EU's cosmetic safety framework. FDA cosmetic facility registration (MoCRA): FEI 3008182565.