30 ml — roughly two monthsContains fish — not veganFormulated in FranceFull INCI published
CELLULAR RENEWAL · NIGHT SERUM · FIRMNESSSalmon polynucleotides — not vegan, stated upfront
For skin that looks rested and full, not thin and tired.
Built on salmon-derived polynucleotides at 5% — the top of the range its supplier has tested — with MossCellTec™ No. 1 at its studied 2%, PhytoCellTec™ Swiss apple fruit cell culture, biotin and hyaluronic acid. Applied at night, when your skin has the face to itself.
5%DNA Gel PH™ — its supplier’s max tested
2%MossCellTec™ — its studied level
−15%crow’s-feet look at 28 days
1%PhytoCellTec™ — study used 2%
60-day refund — opened or not, nothing to send back · Free US shipping · Full INCI published
- Three named actives, each with its percentage printed
- MossCellTec™ No.1 at 2% — its maker's recommended level
- Salmon-derived polynucleotides — contains fish, and not vegan
- Made in France — Europe Cosmétiques & Parfums, Carros
WHY IT WORKS
The corner of the eye, where it shows first.
Where skin creases when you smile and, lately, stays creased a moment longer. MossCellTec™ No. 1 sits here at 2% — exactly the level its own studies used. Measured against placebo over 28 days, the appearance of crow’s-feet wrinkle depth fell 15%.
And in the most punishing test in its file — 23 women through a Seoul summer, moving between outdoor heat and dry air-conditioned offices — every one of the 23 recorded a significant increase in skin hydration on the treated side within 14 days, and 91% recorded lower water loss. That is a responder rate inside one clinical cohort, not a guarantee, but it is a hundred per cent of a real group under conditions worse than your commute.
Alongside it, PhytoCellTec™ Malus Domestica, the world’s first plant stem-cell active in cosmetics and patented in five countries: in its maker’s four-week study, crow’s-feet wrinkle depth fell 8% at two weeks and 15% at four — that study ran at 2% and this serum carries 1%, which we print rather than round away.
And the salmon-derived polynucleotide complex behind in-clinic renewal treatments, at 5%. Made in Carros, France. Results refer to the appearance of skin.
Salmon polynucleotides, at the top of their tested range
The 5%, printed on the box.
DNA Gel PH™ at 5.00% — high-purity polynucleotides from salmon soft roe, fragmented to around 110 kDa: large enough to hold their water-trapping structure, small enough to work. Five per cent is the maximum concentration its supplier has ever tested, which is an unusual place for a brand to end up.
Watch the units when you shop this category. Competitors print numbers like “10,000 ppm”, which sounds enormous and is one per cent of a raw solution. Our 5% delivers 1,500 ppm of polymerised sodium DNA into the finished serum. In the supplier’s evaluation on 10 volunteers over 8 days, it produced a significant increase in the mechanical elasticity and suppleness of skin.
Contains salmon-derived DNA. Not vegan. Not suitable for anyone with a fish allergy. We put that on the front of the page rather than the bottom of the ingredient list.
WHERE THE EVIDENCE STANDS
One number here does not flatter us. It is printed anyway.
If disclosure at this level reads as unusual, that is a statement about the category, not about us.
- Evidence tier
- Supplier research — Mibelle Biochemistry’s ingredient studies, not independent studies of this finished serum.
- Where the clinical weight sits
- MossCellTec™ at 2% and DNA Gel PH™ at 5% — both at, or at the top of, their studied concentrations. The crow’s-feet and hydration numbers on this page come from those two.
- The honest line
- PhytoCellTec™ is included at 1% where its study used 2%. We print the gap rather than round it away, and it rises on the next production run.
- Published with your order
- Full INCI, allergens first: contains fish — not vegan.
HOW TO USE
Night. After cleansing, before moisturiser.
Cleanse
Clean, dry skin — the last face of the day.
Apply
A few drops pressed in, before moisturiser.
Morning after
Nothing to layer, nothing to time. The night step stands alone.
WHAT'S INSIDE
5%, 2%, 1%. Every concentration printed.
Polynucleotides are salmon-derived — which is why this serum is not vegan, and why we say so on the front of the page instead of the bottom of the INCI.
- Salmon polynucleotides — 5% — the renewal compound behind in-clinic treatments, at the top of its supplier’s tested range
- MossCellTec™ No. 1 — 2% — the maker’s level, exactly — this is where the clinical weight sits
- PhytoCellTec™ — 1% — Swiss apple fruit cell culture — its study used 2%, and we print that too
- Biotin + hyaluronic acid — present at trace level — named on the label, claimed nowhere
THE FORMULA, PRINTED
Every active, and how much of it is in the bottle.
Ingredient lists use INCI names, which is why a hero active can hide inside words like “isomalt” or “malus domestica fruit cell culture extract”. So here is the plain version: what we call each active, and how much of it is in the finished serum.
Source: the INCI declaration printed on the carton.
- DNA Gel PH™ · 5.000%
- MossCellTec™ No. 1 · 2.000%
- PhytoCellTec™ Malus Domestica · 1.000%
- Hyaluronic acid
- Biotin — carried in with DNA Gel PH™, not added on its own
The complete INCI list, exactly as it appears on the carton aqua (water), glycerin, isomalt, polysorbate 20, 1,2-hexanediol, hydroxyethylcellulose, propanediol, hydroxyacetophenone, DNA, malus domestica fruit cell culture extract, caprylhydroxamic acid, phenoxyethanol, sodium nitrate, carbomer, xanthan gum, potassium sorbate, disodium phosphate, sodium phosphate, sodium benzoate, sodium hyaluronate, sodium metabisulfite, polysorbate 60, phytol, biotin
The full label — Supplement Facts
The corner of the eye, where it shows first.
Where skin creases when you smile and, lately, stays creased a moment longer.
MossCellTec™ No. 1 sits here at 2% — exactly the level its own studies used. Measured against placebo over 28 days, the appearance of crow's-feet wrinkle depth fell 15%. And in the most punishing test in its file — 23 women through a Seoul summer, moving between outdoor heat and dry air-conditioned offices — every one of the 23 recorded a significant increase in skin hydration on the treated side within 14 days, and 91% recorded lower water loss. That is a responder rate inside one clinical cohort, not a guarantee.
DNA Gel PH™ at 5.00% — high-purity polynucleotides from salmon soft roe, fragmented to around 110 kDa. Five per cent is the maximum concentration its supplier has ever tested. Watch the units when you shop this category: competitors print figures like "10,000 ppm", which sounds enormous and is one per cent of a raw solution. Our 5% delivers 1,500 ppm of polymerised sodium DNA into the finished serum. In the supplier's evaluation on 10 volunteers over 8 days, it produced a significant increase in mechanical elasticity and suppleness.
PhytoCellTec™ Malus Domestica was the first plant stem cell active in cosmetics, and it is patented in five countries. In its maker's four-week study with 20 subjects, a 2% cream applied twice daily to the crow's feet area reduced wrinkle depth by 8% at two weeks and 15% at four, measured by the PRIMOS system.
One number here does not flatter us: PhytoCellTec™ sits at 1% where that study used 2%. We print it anyway, and it rises on the next production run. The clinical weight in this formula is carried by MossCellTec™ at 2% and DNA Gel PH™ at 5% — both at, or at the top of, their studied concentrations.
Applied at night. Made in Carros, France. The research is Mibelle Biochemistry's and Sederma's own, into the ingredients rather than into this finished serum.
Contains fish. The polynucleotide complex is salmon-derived, so this serum is not vegan and is not suitable for anyone with a fish allergy. Patch test 48 hours before first use. For external use only. Avoid the eye area. Results refer to the appearance of skin and vary between individuals.
THE VYVA STANDARD
The VyVa Standard
Every active we use is named, and its amount is printed: milligrams on our supplements, percentages on our serums. There are no proprietary blends, and each product's full formula, its Supplement Facts or its full INCI, is published on its page before you buy.
Everything on this page can be checked. That's the entire pitch.
- 30 ml — roughly two months
- Contains fish — not vegan
- Formulated in France
- Full INCI published
Safety Contains fish. Patch test 48 hours before first use.
Safety For external use only. Avoid the eye area. Patch test 48 hours before first use. Discontinue use if irritation occurs. Use sunscreen when exposed to sunlight. Keep out of reach of children.
Safety Discontinue use and consult a physician if irritation or unexpected reaction occurs. Not recommended for individuals sensitive to any ingredient in this product.
FAQ
Is it vegan?
No. The polynucleotides are salmon-derived. If you have a fish allergy, this serum is not for you.
Why night?
Renewal-focused actives earn their place when skin has the face to itself — no sunscreen, no makeup above them.
Can I pair it with Clarity?
Yes — that’s the Bare Duo: Clarity in the morning, Renewal at night.
When will I see something?
No date. Anyone who gives you one is guessing.
Sixty days. Then decide.
If it isn’t for you, tell us and we’ll refund it — opened or not. Keep the bottle; there’s nothing to send back. Sixty days is a refund window, not a results window.
For external use only. Avoid the eye area. Patch test 48 hours before first use. Discontinue use if irritation occurs. Use sunscreen when exposed to sunlight. Keep out of reach of children. Results refer to the appearance of skin. Individual results may vary. PhytoCellTec and MossCellTec are registered trademarks of Mibelle AG.
